Combination of androgen and estrogen improves asthma by mediating Runx3 expression
Yi He, Binaya Wasti, Yu Yuan, Zhifeng Chen, Wentao Duan, Jingsi Jia, Bing Xiao, Xiufeng Zhang, Jianmin Li, Qingping Zeng, Ma Libing, Shaokun Liu, Xudong Xiang
Abstract
These findings suggest that androgen estrogen combination modulate the Th1/Th2 balance via regulating the expression of Runx3 in BECs, thereby providing experimental evidence supporting androgen and estrogen combination as a novel therapy for asthma.
Topics & Concepts
EstrogenAndrogenMedicineEndocrinologyInternal medicineCancer researchBioinformaticsBiologyHormoneAsthma and respiratory diseasesIL-33, ST2, and ILC Pathways