Modular pooled discovery of synthetic knockin sequences to program durable cell therapies
Franziska Blaeschke, Yan Yi Chen, Ryan Apathy, Bence Dániel, Andy Y. Chen, Peixin Amy Chen, Katalin Sándor, Wenxi Zhang, Zhongmei Li, Cody T. Mowery, Tori N. Yamamoto, William A. Nyberg, Angela To, Ruby Yu, Raymund Bueno, Min Cheol Kim, Ralf Schmidt, Daniel B. Goodman, Tobias Feuchtinger, Justin Eyquem, Chun Ye, Julia Carnevale, Ansuman T. Satpathy, Eric Shifrut, Theodore L. Roth, Alexander Marson
Topics & Concepts
BiologyComputational biologyModular designTranscription factorGeneDrug discoveryFunction (biology)Modularity (biology)T-cell receptorCellSynthetic biologyGeneticsCell biologyBioinformaticsT cellImmune systemComputer scienceOperating systemCAR-T cell therapy researchCRISPR and Genetic EngineeringNanowire Synthesis and Applications