A dual-response fluorescent probe for simultaneously monitoring polarity and ATP during autophagy
Wen‐Li Jiang, Zhiqiang Wang, Zhi-Ke Tan, Guojiang Mao, Junjie Fei, Chunyan Li
Abstract
or starvation induced autophagy in living cells. Interestingly, it is found that that ATP deficiency can induce autophagy to increase lysosome polarity. Furthermore, the probe is applied for imaging the change of polarity and ATP under oxidative stress induced autophagy in zebrafish. Therefore, this work holds great potential for tracking the autophagy procedure by detecting the changes of lysosome polarity and ATP, which makes it a potentially powerful tool for understanding the roles of autophagy in diverse biological processes.
Topics & Concepts
AutophagyFluorescencePolarity (international relations)Dual (grammatical number)Materials scienceBiophysicsCell biologyNanotechnologyOptoelectronicsChemistryBiochemistryBiologyPhysicsOpticsApoptosisCellLiteratureArtSulfur Compounds in BiologyAutophagy in Disease and TherapyCannabis and Cannabinoid Research