Torque teno mini virus as a cause of childhood acute promyelocytic leukemia lacking PML/RARA fusion
Annalisa Astolfi, Riccardo Masetti, Valentina Indio, Salvatore Nicola Bertuccio, Daria Messelodi, Simone Rampelli, Davide Leardini, Matteo Carella, Salvatore Serravalle, Virginia Libri, Jessica Bandini, Stefano Volinia, Marco Candela, Andrea Pession
Abstract
Astolf et al provide the first report of acute promyelocytic leukemia driven by viral insertion into the RARA locus. This represents a clear demonstration of a pathology driven by the member of the anelloviruses, a group of viruses otherwise thought to have minimal or no pathogenic potential.
Topics & Concepts
Acute promyelocytic leukemiaTorque teno virusVirologyMedicineLeukemiaPromyelocytic leukemia proteinImmunologyBiologyGeneticsGenePolymerase chain reactionRetinoic acidRetinoids in leukemia and cellular processesVirus-based gene therapy researchinterferon and immune responses