Characterizing the Pathogenic Potential of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli
Megan T. Zangara, Lena Darwish, Brian K. Coombes
Abstract
phenotypic characterization methods. Identification of a definitive molecular marker of the AIEC pathotype has been elusive; however, significant advancements have been made in understanding the genetic, metabolic, and virulence determinants of AIEC infection biology. Here, we review the current knowledge of AIEC pathogenesis to provide additional, objective measures that could be considered in defining AIEC and their pathogenic potential.
Topics & Concepts
Escherichia coliMicrobiologyCrohn's diseasePathogenic Escherichia coliDiseaseMedicineBiologyPathologyGeneticsGeneAntibiotic Resistance in BacteriaEscherichia coli research studiesGut microbiota and health