ZIF-8 metal organic framework nanoparticle loaded with tense quaternary state polymerized bovine hemoglobin: potential red blood cell substitute with antioxidant properties
Xiangming Gu, Megan Allyn, Katelyn E. Swindle‐Reilly, Andre F. Palmer
Abstract
. Incorporation of PolybHb into the ZIF-8 scaffold resulted in reduced cytotoxicity towards human umbilical vein endothelial cells compared to unloaded ZIF-8 NPs and ZIF-8 NPs loaded with bovine Hb. We envisage that such a monodisperse and biocompatible HBOC with low oxygen affinity and antioxidant properties may broaden its use as an RBC substitute.
Topics & Concepts
HemoglobinNanoparticlePolymerizationAntioxidantRed blood cellChemistryMetalMaterials scienceChemical engineeringNanotechnologyBiochemistryOrganic chemistryPolymerEngineeringHemoglobin structure and functionBiochemical effects in animalsAdvanced NMR Techniques and Applications