Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D<sub>3</sub> Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders
Alessandro Bonifazi, Amy Hauck Newman, Thomas M. Keck, Silvia Gervasoni, Giulio Vistoli, Fabio Del Bello, Gianfabio Giorgioni, Pegi Pavletić, Wilma Quaglia, Alessandro Piergentili
Abstract
R partial agonists. Such a profile might be a promising starting point for the discovery of novel antipsychotic agents.
Topics & Concepts
PharmacophoreChemistryDopamine receptor D2DopaminePharmacologyDrug discoveryCarboxamideStereochemistryReceptorNeuroscienceBiochemistryBiologyReceptor Mechanisms and SignalingPharmacological Receptor Mechanisms and EffectsNeurotransmitter Receptor Influence on Behavior