A copper-catalyzed asymmetric oxime propargylation enables the synthesis of the gliovirin tetrahydro-1,2-oxazine core
Nicholas G. W. Cowper, Matthew J. Hesse, Katie M. Chan, Sarah E. Reisman
Abstract
The bicyclic tetrahydro-1,2-oxazine subunit of gliovirin is synthesized through a diastereoselective copper-catalyzed cyclization of an <italic>N</italic>-hydroxyamino ester.
Topics & Concepts
OximeCatalysisCopperCore (optical fiber)Combinatorial chemistryChemistryOrganic chemistryMaterials scienceComposite materialChemical Synthesis and AnalysisClick Chemistry and ApplicationsSynthesis and Catalytic Reactions