Dauricine regulates prostate cancer progression by inhibiting PI3K/AKT-dependent M2 polarization of macrophages
Mengxuan Li, Nan Che, Xingzhe Liu, Yanhua Xuan, Yu Jin
Topics & Concepts
Macrophage polarizationPI3K/AKT/mTOR pathwayProtein kinase BCancer researchM2 MacrophageProstate cancerMetastasisDownregulation and upregulationTumor microenvironmentMacrophageTumor-associated macrophageChemistrySignal transductionCell biologyBiologyIn vitroMedicineCancerInternal medicineBiochemistryTumor cellsGeneImmune cells in cancerAntimicrobial Peptides and ActivitiesEpigenetics and DNA Methylation