Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells
Han Wang, Chao Wang, Bingru Li, Cangxin Zheng, Guoquan Liu, Zhenming Liu, Liangren Zhang, Ping Xu, Ping Xu
Topics & Concepts
GPX4ChemistryLysosomeCancer cellAutophagyHT1080Lipid peroxidationGlutathione peroxidaseCancerGlutathioneCell biologyCancer researchBiochemistryCellOxidative stressEnzymeApoptosisBiologyGeneticsFerroptosis and cancer prognosisHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and Analysis