Natriuretic Peptides: Role in the Diagnosis and Management of Heart Failure: A Scientific Statement from the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society
Hiroyuki Tsutsui, Nancy M. Albert, Andrew J.S. Coats, Stefan D. Anker, Antoni Bayés‐Genís, Javed Butler, Ovidiu Chioncel, Christopher R. deFilippi, Mark H. Drazner, G. Michael Felker, Gerasimos Filippatos, Mona Fiuzat, Tomomi Ide, James L. Januzzi, Koichiro Kinugawa, Koichiro Kuwahara, Yuya Matsue, Robert J. Mentz, Marco Metra, Ambarish Pandey, Giuseppe Rosano, Yoshihiko Saito, Yasushi Sakata, Naoki Sato, Petar Seferović, John R. Teerlink, Kazuhiro Yamamoto, Michihiro Yoshimura
Abstract
Natriuretic peptides, brain (B-type) natriuretic peptide (BNP) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) are globally and most often used for the diagnosis of heart failure (HF). In addition, they can have an important complementary role in the risk stratification of its prognosis. Since the development of angiotensin receptor-neprilysin inhibitors (ARNIs), the use of natriuretic peptides as therapeutic agents has grown in importance. The present document is the result of the Trilateral Cooperation Project among the Heart Failure Association of the European Society of Cardiology, the Heart Failure Society of America and the Japanese Heart Failure Society. It represents an expert consensus that aims to provide a comprehensive, up-to-date perspective on natriuretic peptides in the diagnosis and management of HF, with a focus on the following main issues: (1) history and basic research: discovery, production and cardiovascular protection; (2) diagnostic and prognostic biomarkers: acute HF, chronic HF, inclusion/endpoint in clinical trials, and natriuretic peptide-guided therapy; (3) therapeutic use: nesiritide (BNP), carperitide (ANP) and ARNIs; and (4) gaps in knowledge and future directions.