Optimization of a series of potent, selective and orally bioavailable SYK inhibitors

Neil P. Grimster, Lakshmaiah Gingipalli, Bernard Barlaam, Qibin Su, Xiaolan Zheng, David Watson, Haixia Wang, Iain Simpson, Andy Pike, Amber Balazs, Scott Boiko, Timothy P. Ikeda, Anna C. Impastato, Natalie H. Jones, Sameer Kawatkar, Paul D. Kemmitt, Scott G. Lamont, Joe Patel, Jon Read, Ujjal Sarkar, Sha Li, Ronald Tomlinson, Haiyun Wang, David M. Wilson, Troy E. Zehnder, Lianghe Wang, Peng Wang, Frederick W. Goldberg, Wenlin Shao, Stephen E. Fawell, Hannah Dry, James J. Dowling, Scott D. Edmondson