<i>N</i> -Carboxyanhydrides directly from amino acids and carbon dioxide and their tandem reactions to therapeutic alkaloids
Thi V. Tran, Yi Shen, Hieu D. Nguyen, Shijie Deng, Hootan Roshandel, Mason Cooper, Jose R. Watson, Jeffery A. Byers, Paula L. Diaconescu, Loi H.
Abstract
A phosgene-free method to prepare N -carboxyanhydrides from amino acids and carbon dioxide has been developed. This method is mild enough to be used in the tandem synthesis of alkaloids tryptanthrin and phaitanthrin A.
Topics & Concepts
PhosgeneChemistryTandemCarbon dioxideAmino acidOrganic chemistryCombinatorial chemistryBiochemistryMaterials scienceComposite materialCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisQuinazolinone synthesis and applications