Novel guanidine derivatives targeting leukemia as selective Src/Abl dual inhibitors: Design, synthesis and anti-proliferative activity
Amr H. Moustafa, Asmaa M. AboulMagd, Ali M. Ali, A. Khodairy, Adel A. Marzouk, Ayman Nafady, Mohamed T. M. Nemr
Topics & Concepts
ChemistryIC50Proto-oncogene tyrosine-protein kinase SrcABLKinaseTyrosine kinaseMAPK/ERK pathwayStereochemistryBiochemistrySignal transductionIn vitroChronic Myeloid Leukemia TreatmentsQuinazolinone synthesis and applicationsResearch on Leishmaniasis Studies