Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19
Na Wang, Marta Vuerich, Ahmadreza Kalbasi, Jonathon J. Graham, Eva Csizmadia, Zachary Manickas-Hill, Ann E. Woolley, Clément N. David, Eric Miller, Kara M. Gorman, Jonathan L. Hecht, Shahzad Shaefi, Simon C. Robson, Maria Serena Longhi
Abstract
could have permissive roles in COVID-19 progression and indicate potential therapeutic targets to reverse disease.
Topics & Concepts
TranscriptomeBiologySpleenPeripheral blood mononuclear cellT-cell receptorImmunologyDownregulation and upregulationLungRepertoireCD8Gene expressionT cellImmune systemGeneMedicineInternal medicineGeneticsAcousticsPhysicsIn vitroImmune Cell Function and InteractionImmune cells in cancerInflammasome and immune disorders