MyD88-Dependent Glucose Restriction and Itaconate Production Control Brucella Infection
Carolyn A. Lacey, Bárbara Ponzilacqua-Silva, Catherine A. Chambers, Alexis S. Dadelahi, Jerod A. Skyberg
Abstract
Brucellosis is one of the most common global zoonoses and is caused by facultative intracellular bacteria of the genus Brucella . Numerous studies have found that MyD88 signaling contributes to protection against Brucella ; however, the underlying mechanism has not been entirely defined.
Topics & Concepts
Brucella melitensisBrucellaBiologyMicrobiologyIntracellular parasiteIn vivoBrucellaceaeProinflammatory cytokineEffectorMacrophageBrucellosisInflammationIn vitroImmunologyIntracellularCell biologyBiochemistryBiotechnologyBrucella: diagnosis, epidemiology, treatmentTrace Elements in HealthBurkholderia infections and melioidosis