The fluorescence imaging and precise suppression of bacterial infections in chronic wounds by porphyrin-based metal–organic framework nanorods
Lihua Zhang, Minzhi Ouyang, Yufei Zhang, Leiyi Zhang, Ziyun Huang, Libei He, Yanli Lei, Zhen Zou, Feng Feng, Ronghua Yang
Abstract
the generation of reactive oxygen species (ROS). Assays of extensive wounds demonstrate that the precise fluorescence-imaging-guided suppression of bacterial infection can significantly reduce the mouse mortality rate and accelerate wound healing. This system provides the opportunity for "precision medicine" relating to chronic wounds and some large-area wounds.
Topics & Concepts
NanorodPorphyrinFluorescenceSinglet oxygenStaphylococcus aureusMetal ions in aqueous solutionMaterials scienceZincMetalChelationFluorescence-lifetime imaging microscopyNanotechnologyBiophysicsPhotochemistryBiomedical engineeringChemistryBacteriaMedicineOxygenOpticsBiologyMetallurgyOrganic chemistryPhysicsGeneticsNanoplatforms for cancer theranosticsAntimicrobial agents and applicationsWound Healing and Treatments