Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA
Haibo Peng, Beibei Xie, Xiaohong Yang, Jiaojiao Dai, Guoxing Wei, Yun He
Abstract
A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), which target macrophages, respond to both acid and cathepsin B, and release vancomycin (Van) rapidly inside macrophages. Man@AP5-Van significantly increases the intracellular concentration of Van, enhancing its antibacterial efficacy against intracellular MRSA.
Topics & Concepts
PillarSupramolecular chemistryIntracellularVancomycinChemistryVesicleAmphiphileAntibioticsDrug deliveryCombinatorial chemistryStaphylococcus aureusNanotechnologyBacteriaBiophysicsBiochemistryMaterials scienceMoleculeCopolymerBiologyOrganic chemistryMembraneGeneticsStructural engineeringPolymerEngineeringSupramolecular Chemistry and ComplexesSupramolecular Self-Assembly in MaterialsMolecular Sensors and Ion Detection