Hospital wastewater as a reservoir for the tigecycline resistance gene cluster tmexCD-toprJ
Yuchen Wu, Ning Dong, Chang Cai, Rong Zhang, Sheng Chen
Abstract
We read with great interest the recent Article by Ning Dong and colleagues1 in The Lancet Microbe on the transmissible, tigecycline-resistant RND efflux pump tmexCD-toprJ that was widely distributed in clinically important pathogens. As a last-resort antibiotic used to treat severe infections caused by antimicrobial-resistant organisms, the efficacy of tigecycline could be compromised by the presence of tmexCD-toprJ. It has been reported that tmexCD1-toprJ1 could be detected in food market sewage, and several variants of tmexCD4-toprJ have been reported so far.
Topics & Concepts
TigecyclineResistance (ecology)Cluster (spacecraft)WastewaterMedicineEnvironmental scienceBiologyGeneticsEcologyEnvironmental engineeringComputer scienceAntibioticsComputer networkAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsEnterobacteriaceae and Cronobacter Research