Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, <i>erm</i> (55)
Barbara A. Brown‐Elliott, Richard J. Wallace, Nancy L. Wengenack, Sean D. Workman, Andrew D. S. Cameron, Georgie Bush, M. Dolores Hughes, Stephanie Melton, Bibiana Gonzalez-Ramirez, Eliana Rodrı́guez, Kavya Somayaji, Courtney Klapperich, Mary Viers, Ayooluwa Bolaji, Emma Rempel, David C. Alexander
Abstract
Macrolides are a mainstay of therapy for infections due to nontuberculous mycobacteria (NTM). Among rapidly growing mycobacteria (RGM), inducible macrolide resistance is associated with four chromosomal 23S rRNA methylase ( erm ) genes.
Topics & Concepts
23S ribosomal RNABiologyPlasmidMicrobiologyGeneticsGeneMycobacteriumNontuberculous mycobacteriaBacteriaRNARibosomeMycobacterium research and diagnosisTuberculosis Research and EpidemiologyQuinazolinone synthesis and applications