Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products
Do-Yeon Kim, So-Yeon Lee, Jae‐Yun Lee, Tae Woong Whon, June‐Young Lee, Che Ok Jeon, Jin‐Woo Bae
Abstract
The human intestine hosts a complex ecosystem of various microorganisms, collectively known as the gut microbiome, which significantly impacts human health. Disruptions in the gut microbiome are linked to various disorders, including gastrointestinal diseases, such as Clostridioides difficile infection and inflammatory bowel disease, as well as metabolic, neurological, oncologic conditions. Fecal microbiota transplantation (FMT) and live biotherapeutic products (LBPs) have emerged as prospective therapeutic procedures to restore microbial and metabolic balance in the gut. This review assesses the latest advancements, challenges, and therapeutic efficacy of FMT and LBPs, highlighting the need for standardization, safety, and long-term evaluation to optimize their clinical application.