Merging C–C σ-bond activation of cyclobutanones with CO<sub>2</sub> fixation <i>via</i> Ni-catalysis
Lorenzo Lombardi, Alessandro Cerveri, Leonardo Ceccon, Riccardo Pedrazzani, Magda Monari, Giulio Bertuzzi, Marco Bandini
Abstract
A carboxylative Ni-catalyzed tandem C–C σ-bond activation of cyclobutanones followed by CO 2 -electrophilic trapping is documented as a direct route to synthetically valuable 3-indanone-1-acetic acids.
Topics & Concepts
ElectrophileCatalysisChemistryTandemYield (engineering)Functional groupCombinatorial chemistryElectrophilic additionStereochemistryMedicinal chemistryOrganic chemistryMaterials scienceMetallurgyPolymerComposite materialCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods