GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
Sijie Huang, Peiyu Xu, Dandan Shen, Ícaro A. Simon, Chunyou Mao, Yangxia Tan, Huibing Zhang, Kasper Harpsøe, Huadong Li, Yumu Zhang, Chongzhao You, Xuekui Yu, Yi Jiang, Yan Zhang, David E. Gloriam, H. Eric Xu
Topics & Concepts
G protein-coupled receptorBiologyReceptor5-HT receptorSerotoninRhodopsin-like receptorsFunctional selectivityTransmembrane domain5-HT7 receptorGs alpha subunitG proteinCell biologyBiophysicsBiochemistryAgonistMetabotropic receptorReceptor Mechanisms and SignalingProtein Kinase Regulation and GTPase SignalingMonoclonal and Polyclonal Antibodies Research