Value of KPNA4 as a diagnostic and prognostic biomarker for hepatocellular carcinoma
Mingxing Xu, Hao Liang, Kun Li, Shu Zhu, Zhicheng Yao, Ruiyun Xu, Nan Lin
Abstract
T cells, neutrophils and macrophages. In addition, KPNA4 expression was significantly associated with T cell exhaustion. KPNA4 mRNA and protein expression levels were significantly higher in cancerous tissue than in normal tissue. Besides, the increased expression of KPNA4 indicated poor overall survival. Univariate and multivariate Cox regression analyses showed KPNA4 could be viewed as an independent risk factor for HCC patients. Moreover, our experimental results were consistent with those obtained from bioinformatic results. These findings revealed KPNA4 may serve as a novel prognostic biomarker and a potential therapeutic target for HCC.
Topics & Concepts
Hepatocellular carcinomaBiomarkerValue (mathematics)Internal medicineOncologyMedicineBiologyMathematicsStatisticsGeneticsRNA modifications and cancerFerroptosis and cancer prognosisHepatocellular Carcinoma Treatment and Prognosis