Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers
Takahiro Ito, Michael J. Young, Ruitong Li, Sidharth Jain, Andreas Wernitznig, John M. Krill-Burger, Christopher T. Lemke, Davide Monducci, Diego J. Rodriguez, Liang Chang, Sanjukta Dutta, Debjani Pal, Brenton R. Paolella, Michael Rothberg, David E. Root, Cory M. Johannessen, Laxmi Parida, Gad Getz, Francisca Vázquez, John G. Doench, Mahdi Zamanighomi, William R. Sellers
Topics & Concepts
BiologyProfiling (computer programming)Gene expression profilingMAPK/ERK pathwayGeneticsComputational biologyCancer researchBioinformaticsKinaseGeneGene expressionComputer scienceOperating systemMicrotubule and mitosis dynamicsMelanoma and MAPK PathwaysCellular Mechanics and Interactions