Cell-active, irreversible covalent inhibitors that selectively target the catalytic lysine of EGFR by using fluorosulfate-based SuFEx chemistry
Guanghui Tang, Wei Wang, Xuan Wang, Ke Ding, SoFong Cam Ngan, Jiao-Yu Chen, Siu Kwan Sze, Liqian Gao, Peiyan Yuan, Xiaoyun Lu, Shao Q. Yao
Topics & Concepts
ChemistryDruggabilityEGFR inhibitorsErlotinibBiochemistryLysineDrug discoveryCovalent bondTarget proteinKinaseCell growthEpidermal growth factor receptorCombinatorial chemistryReceptorAmino acidGeneOrganic chemistryClick Chemistry and ApplicationsPeptidase Inhibition and AnalysisLung Cancer Treatments and Mutations