Organocatalyzed Kabbe condensation reaction for mild and expeditious synthesis of 2,2‐dialkyl and 2‐spiro‐4‐chromanones
Naval Kapuriya, Jasmin Bhalodia, Mrunal A. Ambasana, Rashmi B. Patel, Atul H. Bapodra
Abstract
Abstract An expeditious Kabbe condensation reaction for the synthesis of 2,2‐dialkyl and 2‐spiro‐chroman‐4(1 H )‐ones has been developed using pyrrolidine‐butanoic acid in DMSO as bifunctional organocatalyst. Unlike existing methods, this reaction proceeds at room temperature with high yields, rendering it an attractive method to synthesize a vast variety of privileged 4‐chromones.
Topics & Concepts
ChemistryBifunctionalPyrrolidineCondensationOrganic chemistryCondensation reactionOrganocatalysisReaction conditionsCatalysisCombinatorial chemistryEnantioselective synthesisPhysicsThermodynamicsSynthesis of Organic CompoundsMulticomponent Synthesis of HeterocyclesOxidative Organic Chemistry Reactions