Klebsiella pneumoniae Carbapenemase Variants Resistant to Ceftazidime-Avibactam: an Evolutionary Overview
Claire Amaris Hobson, Gautier Pierrat, Olivier Tenaillon, Stéphane Bonacorsi, Béatrice Berçot, Ella Jaouen, Hervé Jacquier, André Birgy
Abstract
First variants of the Klebsiella pneumoniae carbapenemase (KPC), KPC-2 and KPC-3, have encountered a worldwide success, particularly in K. pneumoniae isolates. These beta-lactamases conferred resistance to most beta-lactams including carbapenems but remained susceptible to new beta-lactam/beta-lactamase inhibitors, such as ceftazidime-avibactam.
Topics & Concepts
Ceftazidime/avibactamAvibactamKlebsiella pneumoniaeCeftazidimeBeta-Lactamase InhibitorsMicrobiologyBiologyDrug resistanceAntibioticsGeneticsEscherichia coliBacteriaGenePseudomonas aeruginosaAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyVibrio bacteria research studies