Shorter telomeres in children with severe asthma, an indicative of accelerated aging
Florencia María Barbé‐Tuana, Lucas Kich Grün, Vinícius Pierdoná, Mariana Migliorini Parisi, Frederico Friedrich, Fátima Theresinha Costa Rodrigues Guma, Leonardo Araújo Pinto, Renato T. Stein, Paulo Márcio Pitrez, Marcus Herbert Jones
Abstract
=0.013). Our results suggest that short telomeres and up-regulated eotaxin-1, features of accelerated aging, could prematurely contribute to a senescent phenotype increasing the risk for early development of age-related diseases in asthma.
Topics & Concepts
EotaxinAsthmaTelomereMedicineImmunologyChemokineCCL11Internal medicineGastroenterologyEosinophilInflammationBiologyGeneGeneticsTelomeres, Telomerase, and SenescenceNeutrophil, Myeloperoxidase and Oxidative MechanismsChronic Obstructive Pulmonary Disease (COPD) Research