1,1-Diaminoazines as organocatalysts in phospha-Michael addition reactions
Aabid A. Wani, Sumit S. Chourasiya, Deepika Kathuria, Prasad V. Bharatam
Abstract
1,1-Diaminoazines can act as effective organocatalysts for the formation of phosphorus-carbon bonds between biphenylphosphine oxide and an activated alkene (Michael acceptor). These catalysts provide the P-C adducts at a faster rate and with relatively better yields in comparison to the organocatalysts employed earlier. The notable advantage is that 1,1-diaminoazines catalyse the reaction even in an aqueous medium with very good yields. Organocatalysis using 1,1-diaminoazines was also successfully carried out between dimethylphosphite and benzylidenemalononitrile under multicomponent conditions.
Topics & Concepts
Michael reactionOrganocatalysisAdductCatalysisChemistryAlkeneOrganic chemistryAqueous solutionAcceptorAddition reactionPhosphorusCarbon fibersCombinatorial chemistryEnantioselective synthesisMaterials sciencePhysicsCondensed matter physicsComposite numberComposite materialChemical Synthesis and AnalysisOrganophosphorus compounds synthesisAsymmetric Synthesis and Catalysis