<i>In situ</i> generation of imines by the Staudinger/aza-Wittig tandem reaction combined with thermally induced Wolff rearrangement for one-pot three-component β-lactam synthesis
Polina Paramonova, Rodion Lebedev, Olga Bakulina, Dmitry Dar’in, Mikhail Krasavin
Abstract
step (acyclic imine generation), it was shown that the outcome of the synthesis is different from that using pre-synthesized and isolated imines. Additionally, this is the first example of the implementation of the Staudinger/aza-Wittig tandem reaction for the preparation of four-membered heterocycles.
Topics & Concepts
Wolff rearrangementTandemStaudinger reactionWittig reactionIn situLactamComponent (thermodynamics)ChemistryCombinatorial chemistryStereochemistryOrganic chemistryMaterials scienceKetenePhysicsThermodynamicsComposite materialSynthesis of β-Lactam CompoundsSynthesis and Biological ActivitySynthesis and Catalytic Reactions