Alternative treatment of fungal infections: Synergy with non‐antifungal agents
Luana Rossato, Marielle Camargo dos Santos, Roxana G. Vitale, Sybren de Hoog, Kelly Ishida
Abstract
Fungal infections are responsible for high mortality rates in immunocompromised and high-risk surgical patients. Therapy failures during the last decades due to increasing multidrug resistance demand innovative strategies for novel and effective antifungal drugs. Synergistic combinations of antifungals with non-antifungal agents highlight a pragmatic strategy to reduce the development of drug resistance and potentially repurpose known compounds with other functions to bypass costly and time-consuming novel drug development.
Topics & Concepts
AntifungalAntifungal drugsAntifungal drugIntensive care medicineDrugDrug resistanceMedicineEchinocandinsPharmacologyBiologyFluconazoleCaspofunginMicrobiologyDermatologyAntifungal resistance and susceptibilityFungal Infections and StudiesNail Diseases and Treatments