Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion
Michael Olson, Erica R. Vander Mause, Sabarinath Venniyil Radhakrishnan, Joshua Brody, Aaron P. Rapoport, Alana L. Welm, Djordje Atanackovic, Tim Luetkens
Topics & Concepts
Chimeric antigen receptorAntigenCell biologyBiologyImmunologyCancer researchChemistryT cellImmune systemCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology