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Metal-free SHN cross-coupling of pyridines with phosphine chalcogenides: polarization/deprotonation/oxidation effects of electron-deficient acetylenes

Pavel А. Volkov, Anton A. Telezhkin, Kseniya O. Khrapova, Nina I. Ivanova, Alexander I. Albanov, Nina K. Gusarova, Б. А. Трофимов

2021New Journal of Chemistry12 citationsDOI

Abstract

Terminal acylacetylenes act as trimodal auxiliaries in SHN cross-coupling of pyridines with phosphine chalcogenides. The reaction proceeds <italic>via</italic> phosphorylation of the pyridine 2 position followed by 2 → 4-migration of phosphoryl moieties.

Topics & Concepts

ChemistryPhosphineDeprotonationPyridineMetalPolarization (electrochemistry)Coupling reactionCoupling (piping)PhotochemistryStereochemistryMedicinal chemistryOrganic chemistryCatalysisPhysical chemistryEngineeringIonMechanical engineeringSulfur-Based Synthesis TechniquesOrganophosphorus compounds synthesisCatalytic C–H Functionalization Methods
Metal-free SHN cross-coupling of pyridines with phosphine chalcogenides: polarization/deprotonation/oxidation effects of electron-deficient acetylenes | Litcius