Design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and β-amyloid aggregation for Alzheimer’s disease
Golaleh Ghotbi, Mohammad Mahdavi, Zahra Najafi, Farshad Homayouni Moghadam, Maryam Hamzeh‐Mivehroud, Soodabeh Davaran, Siavoush Dastmalchi
Topics & Concepts
ChemistryAcetylcholinesteraseButyrylcholinesteraseAchéDonepezilNeuroprotectionThiazoleIC50Docking (animal)Inhibitory postsynaptic potentialBiochemistryEnzymeIn vitroPharmacologyStereochemistryBiologyPathologyNursingNeuroscienceDementiaMedicineDiseaseCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments