Levocetirizine Dihydrochloride-Loaded Chitosan Nanoparticles: Formulation and <i>In Vitro</i> Evaluation
Gülsel Yurtdaş Kırımlıoğlu, A. Alper Öztürk
Abstract
OBJECTIVES: The aim of the present study was to formulate levocetirizine hydrochloride (LCD)-loaded chitosan nanoparticles at submicron level with high entrapment efficiency and prolonged effect for optimizing the plasma drug concentration enhancing bioavailability. MATERIALS AND METHODS: characteristics were evaluated in detail. RESULTS: release profiles indicated prolonged release of LCD from the nanoparticles that followed the Korsmeyer-Peppas kinetic model. CONCLUSION: Chitosan-based LCD-loaded polymeric nanoparticles appear to be a promising drug delivery system for the active agent.
Topics & Concepts
ChitosanZeta potentialDispersityBioavailabilityMaterials scienceNanoparticleDialysis tubingParticle sizeChemical engineeringChromatographyNanotechnologyChemistryPolymer chemistryOrganic chemistryPharmacologyMembraneMedicineBiochemistryEngineeringAdvanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsAdvancements in Transdermal Drug Delivery