Hydrogel-mediated topical delivery of steroids can effectively alleviate psoriasis <i>via</i> attenuating the autoimmune responses
Kajal Rana, Trishna Pani, Somesh K. Jha, Devashish Mehta, Poonam Yadav, Dolly Jain, Manas Kumar Pradhan, Sarita Mishra, Raunak Kar, Betsy Reshma G, Aasheesh Srivastava, Ujjaini Dasgupta, Veena S. Patil, Avinash Bajaj
Abstract
T cells. We further demonstrated that B-Gel mediated reduction of IL-1β, IL-17, and K16 (marker for keratinocyte proliferation) is responsible for alleviation of psoriasis. Therefore, the non-greasy nature of the hydrogel with a cooling effect provides an alternative for topical application of steroids.
Topics & Concepts
PsoriasisMedicineDermatologyDermatology and Skin DiseasesPsoriasis: Treatment and PathogenesisOcular Surface and Contact Lens