Metal-free three-component assemblies of anilines, α-keto acids and alkyl lactates for quinoline synthesis and their anti-inflammatory activity
Lizhu Huang, Lu Yang, Jie‐Ping Wan, Liyun Zhou, Yunyun Liu, Guifeng Hao
Abstract
A metal-free three-component protocol for quinoline synthesis is developed by using alkyl lactates, anilines and α-keto acids. In vitro experiments disclose the attractive anti-inflammatory activity of these quinoline compounds.
Topics & Concepts
ChemistryQuinolineSulfonic acidAlkylTolueneMetalCombinatorial chemistryOrganic chemistrySulfur-Based Synthesis TechniquesMulticomponent Synthesis of HeterocyclesCatalytic C–H Functionalization Methods