Synthesis of <i>N</i>-substituted phthalimides <i>via</i> Pd-catalyzed [4+1] cycloaddition reaction
Chengxian Hu, Lu Wang, Yuanyuan Wu, Yonglong Zheng, Ying Fu, Zhengyin Du
Abstract
An effective approach of Pd-catalyzed [4+1] cycloaddition of 2-iodo- N -phenylbenzamides with difluorocarbene to access of N -substituted phthalimides is developed.
Topics & Concepts
PhthalimidesCycloadditionCatalysisChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryPhthalimideCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions