Simultaneous measurement of acalabrutinib, ibrutinib, and their metabolites in beagle dog plasma by UPLC-MS/MS and its application to a pharmacokinetic study
Zheli Jiang, Lu Shi, Yu Zhang, Guanyang Lin, Yingying Wang
Topics & Concepts
ChemistryChromatographyBeagleIbrutinibTriple quadrupole mass spectrometerPharmacokineticsProtein precipitationHigh-performance liquid chromatographySelected reaction monitoringTandem mass spectrometryMass spectrometryPharmacologyMedicineInternal medicineLeukemiaChronic lymphocytic leukemiaChronic Lymphocytic Leukemia ResearchImmunodeficiency and Autoimmune DisordersLymphoma Diagnosis and Treatment