The role of lncRNA binding to RNA‑binding proteins to regulate mRNA stability in cancer progression and drug resistance mechanisms (Review)
Nianjie Zhang, Kunming Wen
Abstract
Cancer is a disease that poses a serious threat to human health, the occurrence and development of which involves complex molecular mechanisms.Long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) are important regulatory molecules within cells, which have garnered extensive attention in cancer research in recent years.The binding of lncRNAs and RBPs plays a crucial role in the post-transcriptional regulation of mRNA, affecting the synthesis of proteins related to cancer by regulating the stability of mRNA.This, in turn, regulates the malignant biological behaviors of tumor cells, such as proliferation and metastasis, and serves an important role in therapeutic resistance.The present study reviewed the role of lncRNA-RBP interactions in the regulation of mRNA stability in various malignant tumors, with a focus on the molecular mechanisms underlying this regulatory interaction.The aim of the present review was to gain a deeper understanding of these molecular mechanisms to provide new strategies and insights for the precise treatment of cancer. Contents1. Introduction 2. lncRNA acts as a molecular scaffold, promoting the binding of RBPs to mRNA, thereby regulating mRNA stability 3. lncRNA competitively binds to RBPs, inhibiting the binding of RBPs to mRNA, thereby regulating mRNA stability 4. lncRNA affects the nuclear-cytoplasmic localization of RBPs, influencing the amount of RBP bound to mRNA, thereby regulating mRNA stability 5. lncRNA binds to RBPs that recognize m6A modifications, which then further identify and bind to m6A-modified mRNA, thereby regulating mRNA stability 6. Potential therapeutic strategies targeting the molecular mechanisms by which lncRNA binding to RBPs regulates mRNA stability 7. Conclusion and prospects The role of lncRNA binding to RNA-binding proteins to regulate mRNA stability in cancer progression and drug resistance mechanisms (Review)