Sarcopenia Related to Human Immunodeficiency Virus: Protective Effects of Exercise
Rafael Deminice, Vitor H.F. Oliveira, Allison R. Webel, Kristine M. Erlandson
Abstract
We discuss recent evidence supporting the hypothesis that sarcopenia is an emerging health concern among people with human immunodeficiency virus (HIV) because of increasing life expectancy and HIV- and treatment-related comorbidities. We also hypothesize that combined exercise at higher intensity has a key role in managing sarcopenia in this population because it directly (increases muscle strength and stimulates hypertrophy) and indirectly (prevents mitochondrial dysfunction, oxidative stress, and persistent inflammation) counteracts sarcopenia hallmarks.
Topics & Concepts
SarcopeniaLife expectancyMedicineHuman immunodeficiency virus (HIV)PopulationSkeletal muscleLongevityMuscle strengthImmunologyImmunodeficiencyPhysical exerciseAntiretroviral therapyGerontologyBioinformaticsPhysical activityExercise physiologyAutophagyPhysiologyMitochondrionInternal medicineMitophagyHIV-related health complications and treatmentsNutrition and Health in AgingExercise and Physiological Responses