Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis
Hasan Halit Öz, Ee-chun Cheng, Caterina Di Pietro, Toma Tebaldi, Giulia Biancon, Caroline J. Zeiss, Pingxia Zhang, Pamela H. Huang, Sofia S. Esquibies, Clemente J. Britto, Jonas C. Schupp, Thomas S. Murray, Stephanie Halene, Diane S. Krause, Marie E. Egan, Emanuela M. Bruscia
Abstract
monocytes as a neglected contributor to the pathogenesis of CF lung disease and as a therapeutic target for patients with CF, for whom lung hyperinflammation and tissue damage remain an issue despite recent advances in CF transmembrane conductance regulator (CFTR)-specific therapeutic agents.
Topics & Concepts
CCR2NeutrophiliaInflammationLungImmunologyChemokineCystic fibrosis transmembrane conductance regulatorCystic fibrosisFibrosisPathogenesisMedicinePulmonary fibrosisPathologyChemokine receptorInternal medicineNeonatal Respiratory Health ResearchCystic Fibrosis Research AdvancesImmune responses and vaccinations