Ovarian Cancer Risk Variants Are Enriched in Histotype-Specific Enhancers and Disrupt Transcription Factor Binding Sites
Michelle R. Jones, Pei-Chen Peng, Simon G. Coetzee, Jonathan P. Tyrer, Alberto Luiz P. Reyes, Rosario I. Corona, Brian Davis, Stephanie Chen, Felipe Segato Dezem, Ji-Heui Seo, Siddartha Kar, Eileen Dareng, Benjamin P. Berman, Matthew L. Freedman, Jasmine Plummer, Kate Lawrenson, Paul D.P. Pharoah, Dennis J. Hazelett, Simon A. Gayther
Topics & Concepts
EpigenomicsBiologySingle-nucleotide polymorphismGeneticsGenome-wide association studyOvarian cancerMissing heritability problemTranscription factorSNPHuman geneticsEnhancerDNA binding siteGeneComputational biologyCancerDNA methylationGenotypeGene expressionPromoterCancer-related molecular mechanisms researchRNA modifications and cancerOvarian cancer diagnosis and treatment