O-GlcNAcylation of myosin phosphatase targeting subunit 1 (MYPT1) dictates timely disjunction of centrosomes
Caifei Liu, Yingxin Shi, Jie Li, Xuewen Liu, Zhikai Xiahou, Zhongping Tan, Xing Chen, Jing Li
Abstract
GlcNAc, and a fine balance between the OGT/OGA duo is indispensable for successful mitotic divisions.
Topics & Concepts
CentrosomePLK1MitosisCell biologyPhosphataseBiologyProtein subunitMyosin-light-chain phosphataseCyclin-dependent kinase 1KinasePhosphorylationCell cycleCellBiochemistryGeneMicrotubule and mitosis dynamicsGlycosylation and Glycoproteins ResearchUbiquitin and proteasome pathways