microRNA-382 suppresses the progression of pancreatic cancer through the PI3K/Akt signaling pathway by inhibition of Anxa3
Xiaohui Wan, Dongrui Guo, Qi Zhu, Rongfeng Qu
Abstract
This study focused on the mechanism of miR-382 in epithelial mesenchymal transition and lymph node metastasis in PC in relation to Anxa3 and the PI3K/Akt signaling pathway. We found the inhibitory role of miR-382 in PC in vitro and in vivo.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BCancer researchIn vivomicroRNAEpithelial–mesenchymal transitionPancreatic cancerMechanism (biology)MetastasisSignal pathwaySignal transductionChemistryIn vitroMedicineCell biologyCancerBiologyInternal medicineGeneBiochemistryGeneticsPhilosophyEpistemologyPancreatic and Hepatic Oncology ResearchMicroRNA in disease regulationCancer Cells and Metastasis