Ultrasounds-mediated 10-seconds synthesis of chalcones as potential farnesyltransferase inhibitors
Germain Homerin, Adrian Sorin Nica, Amaury Farce, Joëlle Dubois, Alina Ghinet
Topics & Concepts
ChemistryFarnesyltransferaseArylKetoneFarnesyl-diphosphate farnesyltransferaseFarnesyltransferase inhibitorIn vitroClaisen condensationChalconeCell cultureCancer cellCatalysisStereochemistryCombinatorial chemistryBiochemistryCancerOrganic chemistryEnzymePrenylationMedicineBiologyAlkylInternal medicineGeneticsClick Chemistry and ApplicationsSynthesis and biological activityRetinoids in leukemia and cellular processes