Synthesis and Antinociceptive Activity of N-Substituted 4-Aryl-4-oxo-2-[(3-thiophen-2-yl)amino]but-2-enamides
Sergei A. Shipilovskikh, Vladimir Yu. Vaganov, Р. Р. Махмудов, А. Е. Рубцов
Abstract
2-{[5-Aryl-2-oxofuran-3(2H)-ylidene]amino}thiophene-3-carboxylic acid derivatives reacted with substituted amines to give new N-substituted 4-aryl-4-oxo-2-[(3-thiophen-2-yl)amino]but-2-enamides. Antinociceptive activity of the synthesized compounds was studied.
Topics & Concepts
ChemistryArylThiopheneStereochemistryAmino acidMedicinal chemistryOrganic chemistryBiochemistryAlkylChemical synthesis and pharmacological studiesSynthesis of heterocyclic compoundsSynthesis and Reactions of Organic Compounds