Synthesis and Pharmacological Activities of Pyrazole and Oxadiazole Derivatives: a Review
M. S. Vahora, Jeena Jyoti Boruah, Shuvendu Das
Abstract
Abstract Pyrazole and oxadiazole are pharmacologically important heterocyclic cores. Nowadays, these cores are present in a great variety of therapeutics, such as the antipsychotic CDPPB, antidepressant Fezolamide, antiphlogistic Celecoxib, H2-receptor agonist Betazole, HIV integrase inhibitor Reltregravir, antiretroviral Zibotenten, antibacterial Furamizole, antihypertensives tiodazosin and nesapidil, etc. In this review, we describe some synthetic approaches to pyrazole and oxadiazole derivatives along with their pharmacological activities. The review also covers the synthesis of heterocyclic composed of a pyrazole ring fused with an oxadiazole ring.
Topics & Concepts
ChemistryPyrazoleOxadiazoleCombinatorial chemistryOrganic chemistrySynthesis and biological activityMulticomponent Synthesis of HeterocyclesSynthesis and Biological Evaluation