Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Josephine R. Giles, Shin Foong Ngiow, Sasikanth Manne, Amy E. Baxter, Omar Khan, Ping Wang, Ryan P. Staupe, Mohamed S. Abdel-Hakeem, Hua Huang, Divij Mathew, Mark M. Painter, Jennifer E. Wu, Yinghui Huang, Rishi R. Goel, Patrick Yan, Giorgos C. Karakousis, Xiaowei Xu, Tara C. Mitchell, Alexander C. Huang, E. John Wherry
Topics & Concepts
BiologyChromatinEpigeneticsLymphocytic choriomeningitisTranscriptomeEffectorCytotoxic T cellPopulationProgenitor cellStem cellCD8EpigenomicsCell biologyGeneticsGeneGene expressionDNA methylationImmune systemDemographySociologyIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologyCAR-T cell therapy research